Glycopyrrolate for Hyperhidrosis (Excessive Sweating) Online

Glycopyrrolate is prescribed to treat hyperhidrosis (excessive sweating). Glycopyrrolate is in a class of medications called anticholinergics.¹ It blocks the action of the neurotransmitter acetylcholine in the nervous system. Acetylcholine plays a significant role in stimulating sweat production. By blocking its action, anticholinergic drugs help reduce too much sweating.²

Glycopyrrolate comes as a tablet to take by mouth usually two or three times a day. Take on an empty stomach (at least one hour before or two hours after a meal). Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take glycopyrrolate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

In one clinical study, participants experienced relief from hyperhidrosis within approximately two hours.³

The duration of the effects of glycopyrrolate is eight to 12 hours.

The initial dose of glycopyrrolate is 1 milligram (mg) 3 times a day. Your doctor will adjust the dose as needed. However, the dose is usually not more than 8 mg per day.⁴

Glycopyrrolate is not available over the counter and requires a prescription.⁵ You can get a prescription online through telehealth providers like RedBox Rx. Start a low-cost online consult for excessive sweating to see if glycopyrrolate could be right for you.

Glycopyrrolate starts at less than $30 per month with RedBox Rx, one of the lowest prices available. No insurance required.

Before taking glycopyrrolate:

• Tell your doctor and pharmacist if you are allergic to glycopyrrolate, any other medications, or any of the ingredients in glycopyrrolate tablets or solution. Ask your pharmacist for a list of the ingredients.

• Tell your doctor if you are taking extended-release (long-acting) potassium chloride tablets or capsules. Your doctor may tell you not to take glycopyrrolate if you are taking this medication.

• Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amantadine (SYMMETREL); atenolol (Tenormin, in Tenoretic); digoxin (Lanoxin); levodopa (in RYTARY, in Sinemet, in Stavelo); ipratropium (Atrovent); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers or urinary problems; sedatives; tranquilizers; or tricyclic antidepressants such as amitriptyline, amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil) or trimipramine (Surmontil). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with glycopyrrolate, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• Tell your doctor if you have or have ever had glaucoma, difficulty urinating, a blockage or narrowing of your stomach or intestines, paralytic ileus (condition in which digested food does not move through the intestines), toxic megacolon (a serious or life-threatening widening of the intestine) or myasthenia gravis (a disorder of the nervous system that causes muscle weakness). Your doctor may tell you not to take glycopyrrolate.

• Tell your doctor if you have or have ever had enlargement of the prostate, ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), overactive thyroid, high blood pressure, heart failure, irregular or rapid heartbeats, coronary artery disease, hiatal hernia with reflux, disorders of the nervous system, or kidney or liver disease.

• Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding. If you become pregnant while taking glycopyrrolate, call your doctor.

• If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glycopyrrolate.

• You should know that glycopyrrolate may make you drowsy or cause blurred vision. Do not drive a car or operate machinery until you know how this medication affects you.

• You should know that glycopyrrolate reduces the body's ability to cool off by sweating. Avoid being in hot or very warm temperatures. If you experience any of the following symptoms, call your doctor immediately: lack of sweating in hot weather; hot, red skin; decreased alertness; loss of consciousness; fast, weak pulse; fast, shallow breathing or fever.

Unless your doctor tells you otherwise, continue your normal diet while taking glycopyrrolate.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Glycopyrrolate may cause side effects including:

• Dry mouth.

• Blurred vision.

• Vision problems.

• Loss of taste.

• Headache.

• Nervousness.

• Confusion.

• Drowsiness.

• Weakness.

• Dizziness.

• Difficulty falling asleep or staying asleep.

• Upset stomach.

• Nausea.

• Vomiting.

• Constipation.

• Bloated feeling.

• Nasal congestion.

Tell your doctor if any of these symptoms are severe or do not go away.

Glycopyrrolate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Store glycopyrrolate in a closed container at room temperature, away from heat, moisture and direct light. Keep from freezing.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and out of their sight and reach.

Do not keep outdated medicine or medicine no longer needed.

Unneeded medications should be disposed of in special ways to ensure that pets, children and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.

In case of overdose, call the poison control helpline at 1-800-222-1222 or immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all the prescription and nonprescription (over the counter) medicines you are taking, as well as any products such as vitamins, minerals or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• Cuvposa®

• Dartisla® ODT

• Glycate®

• Robinul®

• Robinul Forte®
  

1. International Hyperhidrosis Society

2. National Library of Medicine

3. Korean Journal of Anesthesiology

4. Mayo Clinic

5. Mayo Clinic

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